Reinventing Genome Engineering
Transforming Plants into Green Factories for Sustainable Bioproduction
Development of nuclease-free methods and design of booster modules to improve efficiency of nuclease-based genome editing technologies with unparalleled efficiency of gene targeting in eukaryotic cells via homologous recombination.
High yield expression in plant chloroplasts using self-replicating minichromosomes for production of complex molecules, pigments, proteins, nucleic acids. Biomass champion Spirodella is used as a robust production host.
Our unique transport systems enable shuttling nucleic acids into the mitochondria as a complementary synthetic biology toolbox for bioproduction including inducers of cytoplasmic male sterility for hybrid seed production.
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